Lehrstuhl für Experimentelle Medizin II
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Research Overview

Tumour Suppressor APC

Amer Family of Proteins

Conductin in Cancer

Activin B and renal cell carcinoma


T E R M I N E


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J O B S

Doktoranden
Praktika / Diplom

Publikationen

Prof. Jürgen Behrens

          Originalarbeiten

          Reviews

Martin Sachs

Jean Schneikert

Michel Hadjihannas

Ingrid Wacker



Prof. Jürgen Behrens

Originalarbeiten

Bernkopf, D.B., Hadjihannas, M.V., and Behrens, J. (2015). Negative-feedback regulation of the Wnt pathway by conductin/axin2 involves insensitivity to upstream signalling. J Cell Sci 128, 33-39.

Wacker, I., and Behrens, J. (2014). Activin B antagonizes RhoA signaling to stimulate mesenchymal morphology and invasiveness of clear cell renal cell carcinomas. PloS one 9, e111276.

Schneikert, J., Ruppert, J.G., Behrens, J., and Wenzel, E.M. (2014). different Roles for the axin interactions with the SAMP versus the second twenty amino acid repeat of adenomatous polyposis coli. PloS one 9, e94413.

Kriz, V., Pospichalova, V., Masek, J., Kilander, M.B., Slavik, J., Tanneberger, K., Schulte, G., Machala, M., Kozubik, A., Behrens, J., et al. (2014). beta-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein. J Biol Chem 289, 1128-1141.

Knaup, K.X., Monti, J., Hackenbeck, T., Jobst-Schwan, T., Klanke, B., Schietke, R.E., Wacker, I., Behrens, J., Amann, K., Eckardt, K.U., et al. (2014). Hypoxia regulates the sperm associated antigen 4 (SPAG4) via HIF, which is expressed in renal clear cell carcinoma and promotes migration and invasion in vitro. Mol Carcinog 53, 970-978.

Brauburger, K., Akyildiz, S., Ruppert, J.G., Graeb, M., Bernkopf, D.B., Hadjihannas, M.V., and Behrens, J. (2014). Adenomatous polyposis coli (APC) membrane recruitment 3, a member of the APC membrane recruitment family of APC-binding proteins, is a positive regulator of Wnt-beta-catenin signalling. The FEBS journal 281, 787-801.

Schneikert, J., Vijaya Chandra, S.H., Ruppert, J.G., Ray, S., Wenzel, E.M., and Behrens, J. (2013). Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation. PloS one 8, e68072.

Schaal, U., Grenz, S., Merkel, S., Rau, T.T., Hadjihannas, M.V., Kremmer, E., Chudasama, P., Croner, R.S., Behrens, J., Sturzl, M., et al. (2013). Expression and localization of axin 2 in colorectal carcinoma and its clinical implication. Int J Colorectal Dis 28, 1469-1478.

Pfister, A.S., Tanneberger, K., Schambony, A., and Behrens, J. (2012). Amer2 protein is a novel negative regulator of Wnt/beta-catenin signaling involved in neuroectodermal patterning. J Biol Chem 287, 1734-1741.

Pfister, A.S., Hadjihannas, M.V., Rohrig, W., Schambony, A., and Behrens, J. (2012). Amer2 protein interacts with EB1 protein and adenomatous polyposis coli (APC) and controls microtubule stability and cell migration. J Biol Chem 287, 35333-35340.

Leung, N., and Behrens, J. (2012). Current approach to diagnosis and management of acute renal failure in myeloma patients. Advances in chronic kidney disease 19, 297-302.

Hadjihannas, M.V., Bernkopf, D.B., Bruckner, M., and Behrens, J. (2012). Cell cycle control of Wnt/beta-catenin signalling by conductin/axin2 through CDC20. EMBO Rep 13, 347-354.

Chandra, S.H., Wacker, I., Appelt, U.K., Behrens, J., and Schneikert, J. (2012). A common role for various human truncated adenomatous polyposis coli isoforms in the control of beta-catenin activity and cell proliferation. PloS one 7, e34479.

Tanneberger, K., Pfister, A.S., Kriz, V., Bryja, V., Schambony, A., and Behrens, J. (2011). Structural and functional characterization of the Wnt inhibitor APC membrane recruitment 1 (Amer1). J Biol Chem 286, 19204-19214.

Tanneberger, K., Pfister, A.S., Brauburger, K., Schneikert, J., Hadjihannas, M.V., Kriz, V., Schulte, G., Bryja, V., and Behrens, J. (2011). Amer1/WTX couples Wnt-induced formation of PtdIns(4,5)P2 to LRP6 phosphorylation. The EMBO journal 30, 1433-1443.

Schneikert, J., Brauburger, K., and Behrens, J. (2011). APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC. Hum Mol Genet 20, 3554-3564.

Schietke, R., Warnecke, C., Wacker, I., Schodel, J., Mole, D.R., Campean, V., Amann, K., Goppelt-Struebe, M., Behrens, J., Eckardt, K.U., et al. (2010). The lysyl oxidases LOX and LOXL2 are necessary and sufficient to repress E-cadherin in hypoxia: insights into cellular transformation processes mediated by HIF-1. J Biol Chem 285, 6658-6669.

Mattauch, S., Sachs, M., and Behrens, J. (2010). Liprin-alpha4 is a new hypoxia-inducible target gene required for maintenance of cell-cell contacts. Exp Cell Res 316, 2883-2892.

Kohler, E.M., Brauburger, K., Behrens, J., and Schneikert, J. (2010). Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. Oncogene 29, 1663-1671.

Hadjihannas, M.V., Bruckner, M., and Behrens, J. (2010). Conductin/axin2 and Wnt signalling regulates centrosome cohesion. EMBO Rep 11, 317-324.

Wacker, I., Sachs, M., Knaup, K., Wiesener, M., Weiske, J., Huber, O., Akcetin, Z., and Behrens, J. (2010). Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol 29, 1707-1718.

Kohler, E.M., Chandra, S.H., Behrens, J., and Schneikert, J. (2009). Beta-catenin degradation mediated by the CID domain of APC provides a model for the selection of APC mutations in colorectal, desmoid and duodenal tumours. Hum Mol Genet 18, 213-226.

Behrens, J., and Bader, M. (2009). Efficiency considerations in triangular adaptive mesh refinement. Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 367, 4577-4589.

Nasir O, Wang K, Föller M, Gu S, Bhandaru M, Ackermann TF, Boini KM, Mack A, Klingel K, Amato R, Perrotti N, Kuhl D, Behrens J, Stournaras C, Lang F. (2009). Relative resistance of SGK1 knockout mice against chemical carcinogenesis. IUBMB Life. 61(7):768-76.

Rotte A, Bhandaru M, Föller M, Biswas R, Mack AF, Friedrich B, Rexhepaj R, Nasir O, Ackermann TF, Boini KM, Kunzelmann K, Behrens J, Lang F. (2009). APC sensitive gastric acid secretion. Cell Physiol Biochem. 23(1-3):133-42.

Stemmer V, de Craene B, Berx G, Behrens J. (2008). Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene. 28;27(37):5075-80.

Dehner M, Hadjihannas M, Weiske J, Huber O, Behrens J. (2008). Wnt signaling inhibits Forkhead box O3a-induced transcription and apoptosis through up-regulation of serum- and glucocorticoid-inducible kinase 1. J Biol Chem. 11;283(28):19201-10.

Kohler EM, Derungs A, Daum G, Behrens J, Schneikert J. (2008). Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours. Hum Mol Genet. 1;17(13):1978-87.

Croner RS, Förtsch T, Brückl WM, Rödel F, Rödel C, Papadopoulos T, Brabletz T, Kirchner T, Sachs M, Behrens J, Klein-Hitpass L, Stürzl M, Hohenberger W, Lausen B. (2008). Molecular signature for lymphatic metastasis in colorectal carcinomas. Ann Surg.. 247(5):803-10.

Mierke CT, Zitterbart DP, Kollmannsberger P, Raupach C, Schlötzer-Schrehardt U, Goecke TW, Behrens J, Fabry B. (2008). Breakdown of the endothelial barrier function in tumor cell transmigration. Biophys J. 1;94(7):2832-46.

Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, Hlubek F, Jung A, Strand D, Eger A, Kirchner T, Behrens J, Brabletz T. (2008). The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res. 15;68(2):537-44..

Runz S, Mierke CT, Joumaa S, Behrens J, Fabry B, Altevogt P. (2008). CD24 induces localization of beta1 integrin to lipid raft domains. Biochem Biophys Res Commun. 4;365(1):35-41.

Bauer K, Mierke C, Behrens J. (2007). Expression profiling reveals genes associated with transendothelial migration of tumor cells: a functional role for alphavbeta3 integrin. Int J Cancer.. 1;121(9):1910-8.

Grohmann A, Tanneberger K, Alzner A, Schneikert J, Behrens J. (2007). AMER1 regulates the distribution of the tumor suppressor APC between microtubules and the plasma membrane. J Cell Sci. 1;120(Pt 21):3738-47.

Koch A, Hrychyk A, Hartmann W, Waha A, Mikeska T, Waha A, Schüller U, Sörensen N, Berthold F, Goodyer CG, Wiestler OD, Birchmeier W, Behrens J, Pietsch T. (2007). Mutations of the Wnt antagonist AXIN2 (Conductin) result in TCF-dependent transcription in medulloblastomas. Int J Cancer. 15;121(2):284-91.

Schneikert J, Grohmann A, Behrens J. (2007). Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner. Hum Mol Genet. 15;16(2):199-209.

Iden S, Rehder D, August B, Suzuki A, Wolburg-Buchholz K, Wolburg H, Ohno S, Behrens J, Vestweber D, Ebnet K. (2006). A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep. 7(12):1239-46.

Hadjihannas, M. V., Bruckner, M., Jerchow, B., Birchmeier, W., Dietmaier, W., and Behrens, J. (2006). Aberrant Wnt/beta-catenin signaling can induce chromosomal instability in colon cancer. Proc Natl Acad Sci U S A 103, 10747-10752.

Iden, S., Rehder, D., August, B., Suzuki, A., Wolburg-Buchholz, K., Wolburg, H., Ohno, S., Behrens, J., Vestweber, D., and Ebnet, K. (2006). A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells. EMBO Rep 7, 1239-1246.

Krieghoff, E., Behrens, J., and Mayr, B. (2006). Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention. J Cell Sci 119, 1453-1463.

Kuphal, F., and Behrens, J. (2006). E-cadherin modulates Wnt-dependent transcription in colorectal cancer cells but does not alter Wnt-independent gene expression in fibroblasts. Exp Cell Res 312, 457-467.

Schneikert, J., and Behrens, J. (2006). The canonical Wnt signalling pathway and its APC partner in colon cancer development. Gut.

Schneikert, J., and Behrens, J. (2006). Truncated APC is required for cell proliferation and DNA replication. Int J Cancer 119, 74-79.

Schmitt-Graeff, A., Ertelt-Heitzmann, V., Allgaier, H. P., Olschewski, M., Nitschke, R., Haxelmans, S., Koelble, K., Behrens, J., and Blum, H. E. (2005). Coordinated expression of cyclin D1 and LEF-1/TCF transcription factor is restricted to a subset of hepatocellular carcinoma. Liver Int 25, 839-847.

Koch, A., Weber, N., Waha, A., Hartmann, W., Denkhaus, D., Behrens, J., Birchmeier, W., von Schweinitz, D., and Pietsch, T. (2004). Mutations and elevated transcriptional activity of conductin (AXIN2) in hepatoblastomas. J Pathol 204, 546-554.

Oesterreich, S., Deng, W., Jiang, S., Cui, X., Ivanova, M., Schiff, R., Kang, K., Hadsell, D. L., Behrens, J., and Lee, A. V. (2003). Estrogen-mediated down-regulation of E-cadherin in breast cancer cells. Cancer Res 63, 5203-5208.

Fujita, Y., Krause, G., Scheffner, M., Zechner, D., Leddy, H. E., Behrens, J., Sommer, T., and Birchmeier, W. (2002). Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol 4, 222-231.

Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P. M., Birchmeier, W., and Behrens, J. (2002). Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22, 1184-1193.

Martin, B., Schneider, R., Janetzky, S., Waibler, Z., Pandur, P., Kuhl, M., Behrens, J., von der Mark, K., Starzinski-Powitz, A., and Wixler, V. (2002). The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts. J Cell Biol 159, 113-122.

Schwarz-Romond, T., Asbrand, C., Bakkers, J., Kuhl, M., Schaeffer, H. J., Huelsken, J., Behrens, J., Hammerschmidt, M., and Birchmeier, W. (2002). The ankyrin repeat protein Diversin recruits Casein kinase Iepsilon to the beta-catenin degradation complex and acts in both canonical Wnt and Wnt/JNK signaling. Genes Dev 16, 2073-2084.

Swiercz, J. M., Kuner, R., Behrens, J., and Offermanns, S. (2002). Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology. Neuron 35, 51-63.

Dahmen, R. P., Koch, A., Denkhaus, D., Tonn, J. C., Sorensen, N., Berthold, F., Behrens, J., Birchmeier, W., Wiestler, O. D., and Pietsch, T. (2001). Deletions of AXIN1, a component of the WNT/wingless pathway, in sporadic medulloblastomas. Cancer Res 61, 7039-7043.

Steinhusen, U., Badock, V., Bauer, A., Behrens, J., Wittman-Liebold, B., Dorken, B., and Bommert, K. (2000). Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential. J Biol Chem 275, 16345-16353.

von Kries, J. P., Winbeck, G., Asbrand, C., Schwarz-Romond, T., Sochnikova, N., Dell'Oro, A., Behrens, J., and Birchmeier, W. (2000). Hot spots in beta-catenin for interactions with LEF-1, conductin and APC. Nat Struct Biol 7, 800-807.

Ghadimi, B. M., Behrens, J., Hoffmann, I., Haensch, W., Birchmeier, W., and Schlag, P. M. (1999). Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implications for cell adhesion and signaling. Eur J Cancer 35, 60-65.

Batsche, E., Muchardt, C., Behrens, J., Hurst, H. C., and Cremisi, C. (1998). RB and c-Myc activate expression of the E-cadherin gene in epithelial cells through interaction with transcription factor AP-2. Mol Cell Biol 18, 3647-3658.

Behrens, J., Jerchow, B. A., Wurtele, M., Grimm, J., Asbrand, C., Wirtz, R., Kuhl, M., Wedlich, D., and Birchmeier, W. (1998). Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280, 596-599.

Faraldo, M. L., Rodrigo, I., Behrens, J., Birchmeier, W., and Cano, A. (1997). Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis. Mol Carcinog 20, 33-47.

Zschiesche, W., Schonborn, I., Behrens, J., Herrenknecht, K., Hartveit, F., Lilleng, P., and Birchmeier, W. (1997). Expression of E-cadherin and catenins in invasive mammary carcinomas. Anticancer Res 17, 561-567.

Behrens, J., von Kries, J. P., Kuhl, M., Bruhn, L., Wedlich, D., Grosschedl, R., and Birchmeier, W. (1996). Functional interaction of beta-catenin with the transcription factor LEF-1. Nature 382, 638-642.

Hennig, G., Lowrick, O., Birchmeier, W., and Behrens, J. (1996). Mechanisms identified in the transcriptional control of epithelial gene expression. J Biol Chem 271, 595-602.

Weidner, K. M., Di Cesare, S., Sachs, M., Brinkmann, V., Behrens, J., and Birchmeier, W. (1996). Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176.

Hennig, G., Behrens, J., Truss, M., Frisch, S., Reichmann, E., and Birchmeier, W. (1995). Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene 11, 475-484.

Kasper, M., Behrens, J., Schuh, D., and Muller, M. (1995). Distribution of E-cadherin and Ep-CAM in the human lung during development and after injury. Histochem Cell Biol 103, 281-286.

Plaschke-Schlutter, A., Behrens, J., Gherardi, E., and Birchmeier, W. (1995). Characterization of the scatter factor/hepatocyte growth factor gene promoter. Positive and negative regulatory elements direct gene expression to mesenchymal cells. J Biol Chem 270, 830-836.

Takeda, H., Nagafuchi, A., Yonemura, S., Tsukita, S., Behrens, J., and Birchmeier, W. (1995). V-src kinase shifts the cadherin-based cell adhesion from the strong to the weak state and beta catenin is not required for the shift. J Cell Biol 131, 1839-1847.

Hulsken, J., Birchmeier, W., and Behrens, J. (1994). E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton. J Cell Biol 127, 2061-2069.

Kraus, C., Liehr, T., Hulsken, J., Behrens, J., Birchmeier, W., Grzeschik, K. H., and Ballhausen, W. G. (1994). Localization of the human beta-catenin gene (CTNNB1) to 3p21: a region implicated in tumor development. Genomics 23, 272-274.

Behrens, J., Vakaet, L., Friis, R., Winterhager, E., Van Roy, F., Mareel, M. M., and Birchmeier, W. (1993). Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene. J Cell Biol 120, 757-766.

Fenyves, A. M., Behrens, J., and Spanel-Borowski, K. (1993). Cultured microvascular endothelial cells (MVEC) differ in cytoskeleton, expression of cadherins and fibronectin matrix. A study under the influence of interferon-gamma. J Cell Sci 106 ( Pt 3), 879-890.

Behrens, J., Lowrick, O., Klein-Hitpass, L., and Birchmeier, W. (1991). The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element. Proc Natl Acad Sci U S A 88, 11495-11499.

Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Lochner, D., and Birchmeier, W. (1991). E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113, 173-185.

Mareel, M. M., Behrens, J., Birchmeier, W., De Bruyne, G. K., Vleminckx, K., Hoogewijs, A., Fiers, W. C., and Van Roy, F. M. (1991). Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int J Cancer 47, 922-928.

Schipper, J. H., Frixen, U. H., Behrens, J., Unger, A., Jahnke, K., and Birchmeier, W. (1991). E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res 51, 6328-6337.

Weidner, K. M., Behrens, J., Vandekerckhove, J., and Birchmeier, W. (1990). Scatter factor: molecular characteristics and effect on the invasiveness of epithelial cells. J Cell Biol 111, 2097-2108.

Behrens, J., Mareel, M. M., Van Roy, F. M., and Birchmeier, W. (1989). Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol 108, 2435-2447.


Reviews

Behrens, J. (2006). One hit, two outcomes for VHL-mediated tumorigenesis. Nat Cell Biol. 10(10):1127-8.

Hadjihannas, M. V., and Behrens, J. (2006). CIN By WNT: growth pathways, mitotic control and chromosomal instability in cancer. Cell Cycle 5, 2077-2081.

Croner, R. S., Foertsch, T., Brueckl, W. M., Guenther, K., Siebenhaar, R., Stremmel, C., Matzel, K. E., Papadopoulos, T., Kirchner, T., Behrens, J., et al. (2005). Common denominator genes that distinguish colorectal carcinoma from normal mucosa. Int J Colorectal Dis 20, 353-362.

Behrens, J. (2005). The role of the Wnt signalling pathway in colorectal tumorigenesis. Biochem Soc Trans 33, 672-675.

Behrens, J., and Lustig, B. (2004). The Wnt connection to tumorigenesis. Int J Dev Biol 48, 477-487.

Lustig, B., and Behrens, J. (2003). The Wnt signaling pathway and its role in tumor development. J Cancer Res Clin Oncol 129, 199-221.

Conway, R. M., Cursiefen, C., Behrens, J., Naumann, G. O., and Holbach, L. M. (2003). Biomolecular markers of malignancy in human uveal melanoma: the role of the cadherin-catenin complex and gene expression profiling. Ophthalmologica 217, 68-75.

Huelsken, J., and Behrens, J. (2002). The Wnt signalling pathway. J Cell Sci 115, 3977-3978.

Seidensticker, M. J., and Behrens, J. (2000). Biochemical interactions in the wnt pathway. Biochim Biophys Acta 1495, 168-182.

Huelsken, J., and Behrens, J. (2000). The Wnt signalling pathway. J Cell Sci 113 ( Pt 20), 3545.

Behrens, J. (2000). Cross-regulation of the Wnt signalling pathway: a role of MAP kinases. J Cell Sci 113 ( Pt 6), 911-919.

Behrens, J. (2000). Control of beta-catenin signaling in tumor development. Ann N Y Acad Sci 910, 21-33; discussion 33-25.

Behrens, J. (1999). Cadherins and catenins: role in signal transduction and tumor progression. Cancer Metastasis Rev 18, 15-30.

Birchmeier, W., Behrens, J., Weidner, K. M., Hulsken, J., and Birchmeier, C. (1996). Epithelial differentiation and the control of metastasis in carcinomas. Curr Top Microbiol Immunol 213 ( Pt 2), 117-135.

Birchmeier, W., Hulsken, J., and Behrens, J. (1995). Adherens junction proteins in tumour progression. Cancer Surv 24, 129-140.

Birchmeier, W., Hulsken, J., and Behrens, J. (1995). E-cadherin as an invasion suppressor. Ciba Found Symp 189, 124-136; discussion 136-141, 174-126.

Huelsken, J., Behrens, J., and Birchmeier, W. (1994). Tumor-suppressor gene products in cell contacts: the cadherin-APC-armadillo connection. Curr Opin Cell Biol 6, 711-716.

Birchmeier, W., and Behrens, J. (1994). Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1198, 11-26.

Behrens, J. (1994). Cell contacts, differentiation, and invasiveness of epithelial cells. Invasion Metastasis 14, 61-70.

Behrens, J., and Birchmeier, W. (1994). Cell-cell adhesion in invasion and metastasis of carcinomas. Cancer Treat Res 71, 251-266.

Behrens, J. (1994). Cadherins as determinants of tissue morphology and suppressors of invasion. Acta Anat (Basel) 149, 165-169.

Birchmeier, W., Weidner, K. M., and Behrens, J. (1993). Molecular mechanisms leading to loss of differentiation and gain of invasiveness in epithelial cells. J Cell Sci Suppl 17, 159-164.

Birchmeier, W., Weidner, K. M., Hulsken, J., and Behrens, J. (1993). Molecular mechanisms leading to cell junction (cadherin) deficiency in invasive carcinomas. Semin Cancer Biol 4, 231-239.

Behrens, J. (1993). The role of cell adhesion molecules in cancer invasion and metastasis. Breast Cancer Res Treat 24, 175-184.

Behrens, J., Frixen, U., Schipper, J., Weidner, M., and Birchmeier, W. (1992). Cell adhesion in invasion and metastasis. Semin Cell Biol 3, 169-178.

Birchmeier, W., Behrens, J., Weidner, K. M., Frixen, U. H., and Schipper, J. (1991). Dominant and recessive genes involved in tumor cell invasion. Curr Opin Cell Biol 3, 832-840.

Behrens, J., Weidner, K. M., Frixen, U. H., Schipper, J. H., Sachs, M., Arakaki, N., Daikuhara, Y., and Birchmeier, W. (1991). The role of E-cadherin and scatter factor in tumor invasion and cell motility. Exs 59, 109-126.





Martin Sachs

Struwe E, Berzl G, Schild R, Blessing H, Drexel L, Hauck B, Tzschoppe A, Weidinger M, Sachs M, Scheler C, Schleussner E, Dötsch J. (2010) Microarray analysis of placental tissue in intrauterine growth restriction. Clin Endocrinol (Oxf) 2010 Feb;72(2):241-7.

Mattauch S, Sachs M, Behrens J. (2010) Liprin-a4 is a new hypoxia-inducible target gene required for maintenance of cell-cell contacts. Exp Cell Res 2010 Oct 15;316(17):2883-92.

Kroening S, Solomovitch S, Sachs M, Wullich B, Goppelt-Struebe M. (2009) Regulation of connective tissue growth factor (CTGF) by hepatocyte growth factor in human tubular epithelial cells. Nephrol Dial Transplant 2009 Mar;24(3):755-62.

Wacker I, Sachs M, Knaup K, Wiesener M, Weiske J, Huber O, Akçetin Z, Behrens J. (2009). Key role for activin B in cellular transformation after loss of the von Hippel-Lindau tumor suppressor. Mol Cell Biol 29(7):1707-18

Croner RS, Förtsch T, Brückl WM, Rödel F, Rödel C, Papadopoulos T, Brabletz T, Kirchner T, Sachs M, Behrens J, Klein-Hitpass L, Stürzl M, Hohenberger W, Lausen B. (2008). Molecular signature for lymphatic metastasis in colorectal carcinomas. Ann Surg.. 247(5):803-10.

Lustig, B., Jerchow, B., Sachs, M., Weiler, S., Pietsch, T., Karsten, U., van de Wetering, M., Clevers, H., Schlag, P. M., Birchmeier, W., and Behrens, J. (2002). Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 22, 1184-1193.

Kurz, S. M., Diebold, S. S., Hieronymus, T., Gust, T. C., Bartunek, P., Sachs, M., Birchmeier, W., and Zenke, M. (2002). The impact of c-met/scatter factor receptor on dendritic cell migration. Eur J Immunol 32, 1832-1838.

Grimm, J., Sachs, M., Britsch, S., Di Cesare, S., Schwarz-Romond, T., Alitalo, K., and Birchmeier, W. (2001). Novel p62dok family members, dok-4 and dok-5, are substrates of the c-Ret receptor tyrosine kinase and mediate neuronal differentiation. J Cell Biol 154, 345-354.

Schaeper, U., Gehring, N. H., Fuchs, K. P., Sachs, M., Kempkes, B., and Birchmeier, W. (2000). Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses. J Cell Biol 149, 1419-1432.

Sakkab, D., Lewitzky, M., Posern, G., Schaeper, U., Sachs, M., Birchmeier, W., and Feller, S. M. (2000). Signaling of hepatocyte growth factor/scatter factor (HGF) to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL. J Biol Chem 275, 10772-10778.

Sachs, M., Brohmann, H., Zechner, D., Muller, T., Hulsken, J., Walther, I., Schaeper, U., Birchmeier, C., and Birchmeier, W. (2000). Essential role of Gab1 for signaling by the c-Met receptor in vivo. J Cell Biol 150, 1375-1384.

Scaal, M., Bonafede, A., Dathe, V., Sachs, M., Cann, G., Christ, B., and Brand-Saberi, B. (1999). SF/HGF is a mediator between limb patterning and muscle development. Development 126, 4885-4893.

Niemann, C., Brinkmann, V., Spitzer, E., Hartmann, G., Sachs, M., Naundorf, H., and Birchmeier, W. (1998). Reconstitution of mammary gland development in vitro: requirement of c-met and c-erbB2 signaling for branching and alveolar morphogenesis. J Cell Biol 143, 533-545.

Hartmann, G., Prospero, T., Brinkmann, V., Ozcelik, C., Winter, G., Hepple, J., Batley, S., Bladt, F., Sachs, M., Birchmeier, C., et al. (1998). Engineered mutants of HGF/SF with reduced binding to heparan sulphate proteoglycans, decreased clearance and enhanced activity in vivo. Curr Biol 8, 125-134.

Schaper, F., Siewert, E., Gomez-Lechon, M. J., Gatsios, P., Sachs, M., Birchmeier, W., Heinrich, P. C., and Castell, J. (1997). Hepatocyte growth factor/scatter factor (HGF/SF) signals via the STAT3/APRF transcription factor in human hepatoma cells and hepatocytes. FEBS Lett 405, 99-103.

Birchmeier, W., Brinkmann, V., Niemann, C., Meiners, S., DiCesare, S., Naundorf, H., and Sachs, M. (1997). Role of HGF/SF and c-Met in morphogenesis and metastasis of epithelial cells. Ciba Found Symp 212, 230-240; discussion 240-236.

Weidner, K. M., Di Cesare, S., Sachs, M., Brinkmann, V., Behrens, J., and Birchmeier, W. (1996). Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature 384, 173-176.

Sachs, M., Weidner, K. M., Brinkmann, V., Walther, I., Obermeier, A., Ullrich, A., and Birchmeier, W. (1996). Motogenic and morphogenic activity of epithelial receptor tyrosine kinases. J Cell Biol 133, 1095-1107.

Isakoff, S. J., Yu, Y. P., Su, Y. C., Blaikie, P., Yajnik, V., Rose, E., Weidner, K. M., Sachs, M., Margolis, B., and Skolnik, E. Y. (1996). Interaction between the phosphotyrosine binding domain of Shc and the insulin receptor is required for Shc phosphorylation by insulin in vivo. J Biol Chem 271, 3959-3962.

Yang, Y., Spitzer, E., Meyer, D., Sachs, M., Niemann, C., Hartmann, G., Weidner, K. M., Birchmeier, C., and Birchmeier, W. (1995). Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J Cell Biol 131, 215-226.

Weidner, K. M., Sachs, M., Riethmacher, D., and Birchmeier, W. (1995). Mutation of juxtamembrane tyrosine residue 1001 suppresses loss-of-function mutations of the met receptor in epithelial cells. Proc Natl Acad Sci U S A 92, 2597-2601.

Schwerk, C., Klotzbucher, M., Sachs, M., Ulber, V., and Klein-Hitpass, L. (1995). Identification of a transactivation function in the progesterone receptor that interacts with the TAFII110 subunit of the TFIID complex. J Biol Chem 270, 21331-21338.

Brinkmann, V., Foroutan, H., Sachs, M., Weidner, K. M., and Birchmeier, W. (1995). Hepatocyte growth factor/scatter factor induces a variety of tissue-specific morphogenic programs in epithelial cells. J Cell Biol 131, 1573-1586.

Riethmacher, D., Langholz, O., Godecke, S., Sachs, M., and Birchmeier, C. (1994). Biochemical and functional characterization of the murine ros protooncogene. Oncogene 9, 3617-3626.

Weidner, K. M., Hartmann, G., Naldini, L., Comoglio, P. M., Sachs, M., Fonatsch, C., Rieder, H., and Birchmeier, W. (1993). Molecular characteristics of HGF-SF and its role in cell motility and invasion. Exs 65, 311-328.

Weidner, K. M., Hartmann, G., Sachs, M., and Birchmeier, W. (1993). Properties and functions of scatter factor/hepatocyte growth factor and its receptor c-Met. Am J Respir Cell Mol Biol 8, 229-237.

Weidner, K. M., Sachs, M., and Birchmeier, W. (1993). The Met receptor tyrosine kinase transduces motility, proliferation, and morphogenic signals of scatter factor/hepatocyte growth factor in epithelial cells. J Cell Biol 121, 145-154.

Naldini, L., Tamagnone, L., Vigna, E., Sachs, M., Hartmann, G., Birchmeier, W., Daikuhara, Y., Tsubouchi, H., Blasi, F., and Comoglio, P. M. (1992). Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor. Embo J 11, 4825-4833.

Hartmann, G., Naldini, L., Weidner, K. M., Sachs, M., Vigna, E., Comoglio, P. M., and Birchmeier, W. (1992). A functional domain in the heavy chain of scatter factor/hepatocyte growth factor binds the c-Met receptor and induces cell dissociation but not mitogenesis. Proc Natl Acad Sci U S A 89, 11574-11578.

Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Lochner, D., and Birchmeier, W. (1991). E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 113, 173-185.

Behrens, J., Weidner, K. M., Frixen, U. H., Schipper, J. H., Sachs, M., Arakaki, N., Daikuhara, Y., and Birchmeier, W. (1991). The role of E-cadherin and scatter factor in tumor invasion and cell motility. Exs 59, 109-126.





Jean Schneikert

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Michel Hadjihannas

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